NSF-Simons Center for Mathematical & Statistical Analysis of Biology

PROGRAMMATIC GOALS

The NSF-Simons Center for Center for Mathematical & Statistical Analysis of Biological Systems at Harvard has three programmatic aims: (i) advance our knowledge of complex biological systems using mathematical & computational tools; (ii) develop new mathematics & statistics which describe biological processes; and (iii) train a new generation of researchers in mathematical & computational biology. Just as physics has been intricately allied with mathematics for centuries, we believe that biology will be similarly allied with mathematics going forward. The Center aims to marry these disciplines by training graduate students and postdocs who are experts in mathematics and computation to effectively use their skills to provide a layered understanding of biological complexity. We also host visitors and hold workshops to foster linkages between mathematicians and biologists who embrace the natural complementarity of these disciplines.

 
SCIENTIFIC GOALS

The scientific goals of the Center are also three-fold: (i) reveal how molecular networks within individual cells orchestrate developmental decisions, (ii) discover how proteins and cells self-assemble and self-organize to produce the components of living things, and (iii) understand how biological systems adapt within and beyond the lifespan of individual organisms. We extract general principles which span a broad range of timescales (from milliseconds to millions of years) and length scales (from microns to hundreds of centimeters). To do so, we study a range of experimental systems: viruses, single-celled organisms, tissues, organoids, and multi-celled animals. We build predictive, causal mathematical models that account for biological decision-making, self-organization and adaptation, linking development and evolution.

 

CENTER DIRECTOR

Andrew MURRAY

Director, NSF-Simons Center for Mathematical & Statistical Analysis of Biological Systems
Herchel Smith Professor of Molecular Genetics
Professor of Molecular and Cellular Biology
 

CENTER MANAGEMENT TEAM

Cassandra Extavour

Cassandra EXTAVOUR

Professor of Organismic & Evolutionary Biology and of Molecular & Cellular Biology

L. MAHADEVAN

Lola England de Valpine Professor of Applied Mathematics, of Organismic & Evolutionary Biology, and of Physics;

Faculty Dean of Mather House of Harvard College

Johan PAULSSON

Professor of Systems Biology

Sharad Ramanathan

Sharad RAMANATHAN

Llura & Gordon Gund Professor of Neurosciences and of Molecular & Cellular Biology

Professor of Applied Physics and Stem Cell & Regenerative Biology

 

AFFILIATED FACULTY

Ariel AMir

Ariel AMIR

Assistant Professor of Mathematics and Applied Physics                                                     

Paola ARLOTTA

Professor of Stem Cell & Regenerative Biology

Michael Desai

Michael DESAI

Professor of Organismic & Evolutionary Biology 

Frank DOYLE

John A. & Elizabeth S. Armstrong Professor of Engineering & Applied Sciences      

Victoria D'SOUZA

Professor of Molecular & Cellular Biology

Sean Eddy

Sean EDDY

Elmore C. Patterson Professor of Molecular & Cellular Biology and of Applied Mathematics

Ethan GARNER

John L. Loeb Associate Professor of the Natural Sciences    

Doeke Hekstra

Doeke HEKSTRA

Assistant Professor of Molecular & Cellular Biology

Assistant Professor of Applied Physics     

Samuel Kou

Samuel KOU

Professor of Statistics; Associate of Center of Mathematical Sciences & Applications; Professor in the Department of Biostatistics      

Na Li

Na LI

Assistant Professor of Electrical Engineering and Applied Mathematics

Richard Losick

Richard LOSICK

Maria Moors Cabot Professor of Biology
Howard Hughes Medical Institute Professor  
 

Vinothan MANOHARAN

Wagner Family Professor of Chemical Engineering and Professor of Physics

Xiao-Li MENG

Dean of the Graduate School of Arts & Sciences
Whipple V. N. Jones Professor of Statistics

Daniel Needleman

Daniel NEEDLEMAN

Gordon McKay Professor of Applied Physics and Professor of Molecular & Cellular Biology

Christopher RYCROFT

Associate Professor of Applied Mathematics

David SCADDEN

Gerald and Darlene Jordan Professor of Medicine; Professor of Stem Cell & Regenerative Biology

Chair of the Department of Stem Cell & Regenerative Biology